Functional Interpretation of Igfbp7 Recoding as an Extracellular Mediator of Skeletal Myogenesis

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

1.轉錄組眾多調控機制中,RNA編輯在功能角色上仍懸而未解,特別是編碼區域的RNA編輯物目標。2.透過一系列的整合性實驗,本研究深入探討一編輯目標Igfbp7之重新編碼事件對其結構與功能之影響,並其如何影響成肌發育過程的角色與機制。相關成果將能拓寬瞭解RNA編輯之生理和發育意義。3.此系統性研究策略通過描繪一新型的肌源性調控機制,進而提供了對與肌肉相關疾病之潛在治療方案的見解。

Project IDs

Project ID:PC11208-0620
External Project ID:MOST110-2320-B182-031-MY3
StatusActive
Effective start/end date01/08/2331/07/24

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