Project Details
Abstract
Since the avian influenza A H5N1 infected both 18 humans and thousands of chickens with
6 human deaths in Hong Kong in 1997 and subsequent other avian influenza A viruses were also
isolated from humans in recent years, humans remain living under the threat of getting infected
by avian influenza at any time. The above 2 incidents have also suggested that there is an
increasing incidence in the emergence of new pandemic influenza A strain due to reassortment.
We would like to establish a genomic database for human influenza A virus using 10
endemic strains circulated from 1996 to 2005 in northern Taiwan. Those of selected 10 human
influenza viruses will be obtained from the Department of Clinical Virology, Chang Gung
Memorial Hospital. Our study will be firstly based on the molecular level to investigate eight
segments of each of 10 viruses by sequencing the entire segments of each gene. We will then
compare each 10 sequences from each segment of gene for the last 10 years to monitor their
evolutionary and antigenic changes in human influenza viruses. Subsequently we will compare our
data with other isolates of humans, avian, and swine sequences obtained from the other five
integrated subgroups to see if
i) there is reassortant that has occurred among human, avian, and swine influenza viruses,
particularly in respect of its internal segments of gene;
ii) there is a consensus sequences as genetic markers between human, avian, and swine viruses
can be determined and be selected for future diagnosis;
iii) prediction and monitoring of annual genetic changes for human influenza can be determined
from those of establish databases; and
iv) any virulent marker can be found among human, avian, and swine influenza viruses from the
databases.
Project IDs
Project ID:PD9308-0579
External Project ID:NSC93-2317-B182-001
External Project ID:NSC93-2317-B182-001
Status | Finished |
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Effective start/end date | 01/08/04 → 31/07/05 |
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