Gene Database Establishment of Human Influenza Virus (Northland Taiwan,1996-2005) to Compare with Animal Influenza Genes for Finding the Genetic Markers in Diagnosis

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details


Since the avian influenza A H5N1 infected both 18 humans and thousands of chickens with 6 human deaths in Hong Kong in 1997 and subsequent other avian influenza A viruses were also isolated from humans in recent years, humans remain living under the threat of getting infected by avian influenza at any time. The above 2 incidents have also suggested that there is an increasing incidence in the emergence of new pandemic influenza A strain due to reassortment. We would like to establish a genomic database for human influenza A virus using 10 endemic strains circulated from 1996 to 2005 in northern Taiwan. Those of selected 10 human influenza viruses will be obtained from the Department of Clinical Virology, Chang Gung Memorial Hospital. Our study will be firstly based on the molecular level to investigate eight segments of each of 10 viruses by sequencing the entire segments of each gene. We will then compare each 10 sequences from each segment of gene for the last 10 years to monitor their evolutionary and antigenic changes in human influenza viruses. Subsequently we will compare our data with other isolates of humans, avian, and swine sequences obtained from the other five integrated subgroups to see if i) there is reassortant that has occurred among human, avian, and swine influenza viruses, particularly in respect of its internal segments of gene; ii) there is a consensus sequences as genetic markers between human, avian, and swine viruses can be determined and be selected for future diagnosis; iii) prediction and monitoring of annual genetic changes for human influenza can be determined from those of establish databases; and iv) any virulent marker can be found among human, avian, and swine influenza viruses from the databases.

Project IDs

Project ID:PD9308-0579
External Project ID:NSC93-2317-B182-001
Effective start/end date01/08/0431/07/05


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