Project Details
Abstract
Development of a complex multicellular organism from a single fertilized egg is one of the most
complicated processes in biology, and it is tightly regulated by genetic networks. The development of
external sensory (ES) organ in fruitfly Drosophila melanogaster provides a genetically advantageous system
to study how genes function and interact with each other during development.
Because of the complexity of the biological processes and the limitation of the genetic and molecular
approaches, it is difficult to analyze the dynamics of the whole genetic networks. To further understand how
genes work within a complex network, our group and Dr. Hsu’s group have developed a computer simulated
model to study the fate specification of external sensory organ precursor (SOP). SOP specification is
determined by the expression of bHLH-type proneural protein and the Delta-Notch signaling pathway.
Integrated studies of in-vivo approaches and the computational simulation have revealed novel insight in
genetic regulation of SOP specification. In this grant, we propose to perform the following genetic
experiments to further understand the complex genetic circuit in SOP development, and also to test the
hypothesis obtained from the simulated model:
1. Pathway specificity and redundancy in selection of Drosophila sensory organ precursors.
2. Functions of Delta in positioning of SOP.
3. Genetic screening for novel components in regulating phyllopod expression in SOP formation.
Project IDs
Project ID:PA9408-0971
External Project ID:NSC94-2627-M182-001
External Project ID:NSC94-2627-M182-001
Status | Finished |
---|---|
Effective start/end date | 01/08/05 → 31/07/06 |
Keywords
- SOP
- proneural
- pathway
- Delta
- phyllopod
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