Glutamine Blockades Mitigate Renal Fibrosis by Targeting Immune Cell Subsets – from Single Cell Rna-Seq, Epigenetics, to Immunometabolism Mechanism( I )

Yang, Huang-Yu (PI)
Chen, Yung Chang (CoPI)
Yang, Chih-Wei (CoPI)

School of Medicine

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Abstract

本提案將是第一個關注麩醯胺酸剝奪如何介導 T 細胞和巨噬細胞譜系中的表觀遺傳和代謝組學調節的研究。我們將利用麩醯胺酸抑製劑治療小鼠 UUO 模型，以監測細胞相互作用和治療反應，以作為一種未來的臨床應用的新型抗纖維化療法。

Project IDs

Project ID:PC11207-2255
External Project ID:NSTC112-2314-B182-056

Status	Finished
Effective start/end date	01/08/23 → 31/07/24

Keywords

Kidney fibrosis
Glutamine
Epigenetics
Metabolomics

Access Project

https://www.grb.gov.tw/search/planDetail?id=15484840