Glutamine Blockades Mitigate Renal Fibrosis by Targeting Immune Cell Subsets – from Single Cell Rna-Seq, Epigenetics, to Immunometabolism Mechanism( I )

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

本提案將是第一個關注麩醯胺酸剝奪如何介導 T 細胞和巨噬細胞譜系中的表觀遺傳和代謝組學調節的研究。我們將利用麩醯胺酸抑製劑治療小鼠 UUO 模型,以監測細胞相互作用和治療反應,以作為一種未來的臨床應用的新型抗纖維化療法。

Project IDs

Project ID:PC11207-2255
External Project ID:NSTC112-2314-B182-056
StatusActive
Effective start/end date01/08/2331/07/24

Keywords

  • Kidney fibrosis
  • Glutamine
  • Epigenetics
  • Metabolomics

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