Glutamine fuels the progress of lupus nephritis - Understanding from metabolomics, epigenetics to immunopathogenesis

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Project Details

Abstract

本研究為麩醯胺酸透過代謝免疫和表觀遺傳，調控調節性T細胞（Treg）和輔助T細胞17(Th17)平衡的先驅研究。我們將解碼麩醯胺酸缺乏影響狼瘡活動的關鍵機轉，透過高通量篩選麩醯胺酸代謝關鍵的麩醯胺酸酶抑制劑，形成新型治療策略治療狼瘡小鼠。此研究不僅通過這種創新的自體免疫腎病機制為腎臟學界帶來全新見解。發展麩醯胺酸酶抑制劑治療狼瘡腎炎，將有助生物科技產業。因此，本研究不僅帶來學術前瞻觀點，還可能有助經濟產業和社會發展。

Project IDs

Project ID:PC11006-0067
External Project ID:MOST109-2314-B182-054-MY3
StatusFinished
Effective start/end date01/08/21 → 31/07/22

Keywords

  • Glutamine
  • Epigenetics
  • metabolomics
  • HIF-1

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