Immunological Study on Chronic C Hepatitis (II) Immunopathology and Autologous Hepatocyte Cytotoxicity Assay with Blocking Test

  • Liaw, Yun-Fan (PI)

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

在慢性C型肝炎的致病機制中,過去有關的研 究指出細胞免疫反應扮演重要的角色.過去一 年的研究,發現T細胞扮演的致病機制應是慢性C 型肝炎的主因.然而,何種T細胞(T4細胞或者T8細 胞)才是慢性C型肝炎致病機轉的主角,值得進一 步的探討.因此本研究擬選擇臨床病理確定之 慢性C型肝炎病人五十位,一方面以單核抗體進 行肝組織中浸潤細胞及肝細胞中C型病毒的免 疫病理研究,另一方面利用肝生檢時同時抽取的血液分離出T4細胞/T8細胞進行體外自體肝細 胞的毒殺試驗及阻斷試驗.期以更進一步瞭解C 型肝炎的致病機制作為將來的治療提供理論基 礎.

Project IDs

Project ID:PB8303-1066
External Project ID:NSC83-0419-B182-002-MH
StatusFinished
Effective start/end date01/08/9330/09/94

Keywords

  • Hepatitis C virus
  • Chronic type C hepatitis
  • Autologous hepatocytecytotoxicity assay
  • Immunopathology

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