Impact of glycemia on incidence, presentation, and therapeutic outcome of thyroid cancer

  • Lin, Jen-Der (PI)
  • Chao, Tzu-Chieh (CoPI)
  • Chiou, Wen-Ko (CoPI)
  • Hsueh, Chuen (CoPI)

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

This study will investigate the relationship between type 2 diabetes mellitus (DM) and cancer in hospitalized patients. In addition, thyroid cancer patients with or without type 2 DM will be studied for clinical presentation, therapeutic outcome, and long-term cardiovascular risk. The proposal, which will be retrospectively analyzed and prospectively designed, will examine the frequency of different forms of cancer among male and female patients with or without DM, admitted to a single hospital in Taiwan between January 2001 and December 2010. In our pilot study, the relationship between type 2 DM and mortality in different types of cancers was examined, and it was revealed that type 2 DM increased the total mortality more in thyroid cancer than in other types of cancers. A database containing 3500 thyroid cancer cases will be further investigated, and an estimated 300 new thyroid cancer patients will be enrolled. Anthropometric data and biochemical data with serum glycemic and cardiovascular risk factors, including 1,5-anhydroglucitol, HbA1c, immunoreactive insulin, glucagon-like peptide-1 (GLP-1), E-selectin, and vascular cell adhesion molecule-1 (VCAM-1) will be determined in long-term follow up in 300 well-differentiated thyroid cancer DM or non-DM patients. Tissue expression of GLP-1 receptor and E-selectin in cancer cells or endothelial cells (by immunohistochemical staining and mRNA analysis) will be determined in 300 high-risk patients with well-differentiated thyroid cancer. We anticipate that hyperinsulinemia in overweight or early type 2 DM patients may increase oncogenesis in most tissues. Thyroid cancer patients with diabetes associated with higher levels of circulating biomarkers of endothelial cell adhesion (E-selectin), GLP-1, and VCAM-1 may have poor prognosis. The dual effects of cardiovascular morbidities and cancer cell growth and migration may aggravation therapeutic outcomes. These studies may conclude that the enhanced activation of the endothelium places the patients with diabetes at increased risk of morbidity and mortality.

Project IDs

Project ID:PC10202-0819
External Project ID:NSC101-2314-B182-038-MY2
StatusFinished
Effective start/end date01/08/1331/07/14

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