Impact of Posttranslational Modification of Ns2 by Ubiquitin on Influenza a Virus

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

本研究計畫將探討宿主泛素連接酶及去泛素酶如何拮抗調控A型流感病毒NS2蛋白質的後轉譯修飾,並發展一套活體影像系統深入探討NS2泛素後轉譯修飾如何增進病毒基因體複製,及病毒基因體運送出細胞核組裝成病毒子代。了解此調控機制,將能進一步發展抑制病毒繁衍的策略,減低A型流感病毒傳播與感染。

Project IDs

Project ID:PC11307-1326
External Project ID:NSTC113-2320-B182-010
StatusActive
Effective start/end date01/08/2431/07/25

Keywords

  • Influenza A virus
  • NS2
  • deubiquitinase
  • Ubiquitin E3 ligase

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