In Utero Exposure to Autoantigens: Reappraisal of Tolerance Induction and Underlying Mechanisms

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

本計劃為利用自體抗原進行胎內注射,以評估胎兒免疫系統對自體抗原可能誘發耐受或致敏反應,是否因自體抗原特性、曝露劑量不同而有差異。本研究將是首度從自體抗原面向,對免疫學的核心基柱【主動誘導獲得耐受】(actively acquired tolerance)論述進行徹底評估。同時也將深入探討胎兒巨噬細胞吞噬抗原後,在溶小體內進行抗原裂解、傳訊的分子生物學機制對胎內耐受或致敏的影響。本研究的結果能拓展免疫耐受誘導的相關知識及技術,亦或提供自體免疫疾病可能相關的致病機轉。因此本計畫結果在基礎免疫學,移植耐受及自體免疫疾病方面皆可產生相關的貢獻及影響。

Project IDs

Project ID:PC11107-4662
External Project ID:MOST109-2314-B182-041-MY3
StatusFinished
Effective start/end date01/08/2231/07/23

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