Integrative Investigation of the Association between Mutations in the Squalene Epoxidase, Biological Characteristics, and Antifungal Resistance in Dermatophytes and Establish a Web-Based Nanopore Sequencing System for Rapid Identification and Prediction of Dermatophyte Resistance

Sun, Pei-Lun (PI)
Huang, Yin Tse (CoPI)
Lin, Shu-Yi (CoPI)

School of Medicine

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Abstract

本計畫的目的在深入了解抗藥性菌株的生物學及分子特性，建立形態及分子鑑定和預測抗藥性的網路平台。此研究成果，有助於了解角鯊烯環氧化酶在皮癬菌抗藥性扮演的角色，而建立的抗藥性篩檢網路系統，將可大幅縮短臨床醫師取得檢驗結果的時間，選用合適的藥物，避免過度使用單一藥物導致新的抗藥性。此系統除了能解決目前臨床面臨的迫切問題之外，結合奈米孔定序技術的鑑定平台能同時處理大量檢體，非常適合進行大規模的流行病學追蹤之用。

Project IDs

Project ID:PC11407-5367
External Project ID:NSTC114-2314-B182-035-MY3

Status	Active
Effective start/end date	01/08/25 → 31/07/26

Keywords

dermatophytes
resistance
nanopore sequencing
squalene epoxidase

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https://www.grb.gov.tw/search/planDetail?id=18011956

Integrative Investigation of the Association between Mutations in the Squalene Epoxidase, Biological Characteristics, and Antifungal Resistance in Dermatophytes and Establish a Web-Based Nanopore Sequencing System for Rapid Identification and Prediction of Dermatophyte Resistance

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Abstract

Project IDs

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