Integrative Role of the Na+/K+-Atpase in the Central Clock of the Rat Suprachiasmatic Nucleus: Na+/K+-Atpase Α-Isoforms Specific Distribution, Rhythmic Expression, and Physiological Functions

  • Huang, Rong-Chi (PI)

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Project Details

Abstract

SCN時鐘神經元的電位發射頻率、鈣離子濃度，鈉鈣交換子活性、葡萄糖吸收、cytochrome oxidase，以及鈉鉀幫浦活性等都有日高夜低的節律。我們認為鈉鉀幫浦可能扮演整合這些節律的角色。尤其是SCN時鐘神經元表現α2而非α3，而且α2連同α1都有節律，因此了解鈉鉀幫浦α1尤其是α2如何影響細胞活性、鈉、鈣離子、以及如何影響鈣離子調節者、甚至glutamate誘發鈣訊號的作用，將有助說明鈉鉀幫浦在SCN時鐘的功能角色。執行本計畫或許能協助深入了解鈉鉀幫浦在SCN時鐘的功能角色，甚至回答SCN時鐘神經元為何表現α2而非α3的原因。

Project IDs

Project ID:PC11107-4816
External Project ID:MOST111-2320-B182-008
StatusFinished
Effective start/end date01/08/22 → 31/07/23

Keywords

  • suprachiasmatic nucleus (SCN)
  • circadian rhythm
  • energy metabolism
  • membrane excitability
  • Na+/K+-ATPase (NKA)
  • intracellular Ca2+
  • glutamate
  • ouabain
  • Na+/Ca2+-exchanger (NCX)

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