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Investigate the Potential of Utilizing Bioadhesive Nanoparticle Nasal Spray to Protect and Expedite the Tissue Repair of Nasal Epithelium

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

慢性鼻竇炎患者常因鼻腔上皮損傷而引發持續性發炎,導致鼻塞、流膿及嗅覺受損等症狀,對生活品質造成重大影響。雖然手術能暫時緩解症狀,但術後仍需依賴鼻腔沖洗與類固醇治療以降低復發風險。然而,長期使用類固醇可能引發嚴重副作用,使得現有治療選擇受限。本研究旨在探索一種創新療法,利用新型奈米黏著藥物載體噴劑(NANO-ADC),透過減少發炎反應並促進鼻腔上皮再生,從源頭抑制慢性鼻竇炎的發展。NANO-ADC採用安全的生物材料設計,具抗發炎和修復功能,為患者提供一種安全、長效且高效的治療策略,有望成為慢性鼻竇炎管理的新突破。

Project IDs

Project ID:PC11407-5313
External Project ID:NSTC114-2314-B182-030-MY3
StatusActive
Effective start/end date01/08/2531/07/26

Keywords

  • Chronic Sinusitis
  • 3D Cell Culture
  • Nanoparticle drug carrier
  • bioadhesive
  • Re-Epithelization
  • Wound Healing

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