Project Details
Abstract
帕金森病是最常見的神經元病變性動作障礙疾病，大多數(~90 %)的帕金森病病患屬於偶發型病例，約10 %的病例是遺傳型帕金森病，經由研究遺傳型帕金森病我們會更加了解帕金森病的分子病理路徑。分子遺傳學研究顯示LRP10的基因突變引起顯性遺傳型帕金森病，我們將探討LRP10基因之(G603R)突變或(1424+5delG)突變引起帕金森病的分子病理機轉。患有偶發型帕金森病的漢人病患也具有LRP10基因之突變，相同的分子病理機轉很可能引起LRP10基因之突變造成的遺傳型帕金森病與偶發型帕金森病，因此探討LRP10之基因突變引起遺傳型帕金森病的致病機轉將有助於瞭解偶發型帕金森病之分子病理機轉。
Project IDs
Project ID:PC11207-0498
External Project ID:MOST110-2320-B182-003-MY3
External Project ID:MOST110-2320-B182-003-MY3
| Status | Finished |
|---|---|
| Effective start/end date | 01/08/23 → 31/07/24 |
Keywords
- Autosomal dominant Parkinson's disease
- Low density lipoprotein receptor-related protein 10
- Substantia nigra dopaminergic neurons
- LRP10+/- knockout mouse
- Mutant (G603R) LRP10 knockin mouse
- Alpha-synuclein
- ER stress-induced apoptotic pathway
- Mitochondrial dysfunction
- Mitochondrial oxidative stress
- Mitochondrial apoptotic pathway.
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.