Project Details
Abstract
帕金森病是最常見的神經元病變性動作障礙疾病，基因突變是造成帕金森病的重要致病機轉。基因定序研究發現II-A型蛋白質去磷酸酶B' delta調節次體(PPP2R5D)的新生單股錯義突變引起歐美與漢人病患的帕金森病，經由研究基因突變型帕金森病我們會更加了解帕金森病的分子病理路徑。大多數的帕金森病病患屬於偶發型病例，具有PPP2R5D基因突變的帕金森病病患與偶發型帕金森病病患呈現相同的臨床症狀，相同的分子病理機轉很可能引起PPP2R5D基因之突變造成的帕金森病與偶發型帕金森病，因此探討突變PPP2R5D引起帕金森病的致病機制將有助於瞭解偶發型帕金森病之分子病理機轉。
Project IDs
Project ID:PC11307-1078
External Project ID:NSTC113-2320-B182-026-MY3
External Project ID:NSTC113-2320-B182-026-MY3
| Status | Active |
|---|---|
| Effective start/end date | 01/08/24 → 31/07/25 |
Keywords
- Parkinson's disease
- PPP2R5D
- Substantia nigra pars compacta dopaminergic neurons
- Protein phosphatase 2A
- Phospho-nucleophosminSer125
- Phospho-DiGeorge syndrome critical region 8Ser377
- Phospho-methyl-CpG binding protein 2Ser80
- Mutant (E192K) Ppp2r5d knockin mouse
- p53-mediated apoptotic pathway
- miRNAs
- BDNF.
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