Investigating the Biological Mechanisms and Potential Treatment Strategies of Mechanical Abrasion Induced by Long-Term of Betel Quid Chewing

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

我們在此計畫中,建立體外細胞磨損模式,及口腔癌人源化動物小鼠模式,探討口腔細胞因長期慢性摩擦引起的損傷,所引發腫瘤發展相關基因及生物路徑的變化,以及免疫藥物治療成效。我們證實,口腔細胞在機械性磨損之後,確實引起發炎體的活化,致癌基因表現量增加,同時也發現HIF-1a/ASC/NLRP3複合體,在細胞磨損之後參與啟動腫瘤發展相關基因的重要角色。我們也將進行空間轉錄體學實驗,及蛋白質基因體學數據分析,探討經由磨損引發的腫瘤微環境的生物機轉,以建立因嚼食檳榔的摩擦效應所引起的口腔癌檢測,治療與預防策略。此研究對於口腔癌的醫藥衛生領域,具有重要的發展潛力。

Project IDs

Project ID:PC11207-1378
External Project ID:NSTC112-2314-B182-047
StatusActive
Effective start/end date01/08/2331/07/24

Keywords

  • OSCC
  • in vitro mechanical cell abrasion model
  • MCA
  • LT-MCA
  • OSCC-humanized mouse model
  • spatial transcriptome
  • proteogenomic analysis

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