Investigating the Drug-Nutrient Interaction of Bioactive Compounds in Dietary Supplements Mediated by Inhibition and Induction of the Atp-Binding Cassette Transporters Abcb1 and Abcg2

Wu, Chung-Pu (PI)
Hung, Tai-Ho (CoPI)

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Abstract

醫療專業人員廣泛認為食物-藥物相互作用可能導致藥物動力學和/或藥物動力學特性的變化，或導致副作用。因此我們有必要加強對食物-藥物相互作用的理解。透過利用虛擬篩選小分子天然物數據庫的方法，我們能系統性的分析那些能夠結合ABC蛋白的結構和骨架進行分析，並預測ABC蛋白介導的食物-藥物相互作用。

Project IDs

Project ID:PB11307-2462
External Project ID:NSTC113-2320-B182-021

Status	Active
Effective start/end date	01/08/24 → 31/07/25

Keywords

Drug-nutrient interaction
Dietary supplements
ATP-binding cassette transporters
P-glycoprotein
ABCG2

Access Project

https://www.grb.gov.tw/search/planDetail?id=16560772