Project Details
Abstract
Thrombomodulin (TM), a thrombin receptor on the endothelial cell surface, inhibits the
pro-coagulant functions of thrombin and acts as a protein cofactor in thrombin-catalyzed
activation of protein C. According to the widely expression patterns of TM on various cell
types, our studies had evidenced that different TM domains participate in the regulations of
cell-cell adhesion, tumor growth, angiogenesis, inflammation, and epithelial-mesenchymal
transition. Recent reports proposed that bone marrow-derived mesenchymal stem cells
(BM-MSCs) are specifically recruited to the stroma of developing tumors, which affects the
tumor growth and metastasis. Moreover, it was found that TM is up-regulated on BM-MSCs
upon its exposure to tumor cell conditioned medium, but the physiological function of TM in
BM-MSCs remains unknown. Therefore, exploring the role of TM on BM-MSCs will help
us to understand the biological role of TM on stem cells and may result in a new perspective
on TM’s application for targeting and treating tumors. TM gene-targeting transgenic mouse
isolated BM-MSCs will be used as a research model to implement four specific aims of this
project, including (1) investigating the effect of TM deletion on BM-MSC’s differentiations,
(2) determining the effect of TM deletion on BM-MSC’s biological activities, (3) exploring
the molecular mechanism of TM expression and TM-mediated signaling pathways on
BM-MSCs, and (4) examining the effect of TM deletion on BM-MSC-mediated tumor
progression-related functions.
Project IDs
Project ID:PC10005-0027
External Project ID:NSC100-2320-B182-004
External Project ID:NSC100-2320-B182-004
Status | Finished |
---|---|
Effective start/end date | 01/08/11 → 31/07/12 |
Keywords
- Thrombomodulin
- TM gene-targeting transgenic mouse
- bone marrow-derived mesenchymal stem cells
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.