Investigating the Important Role of Host Protein Iqgap1 in Viral Infection and Extracellular Vesicles

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

本計劃將深入探討宿主蛋白 IQGAP1 為幫助EV-A71感染後促進複製胞器的形成,並影響到EV-A71的複製,同時,也闡明這種宿主蛋白會協助腸病毒感染細胞形成外泌體,增加病毒感染機率。同時,進一步利用動物實驗來確認抑制IQGAP1的藥物或是knockout IQGAP1表現是否能抑制EV-A71感染,對於開發抗腸病毒臨床藥物的研究有所幫助。

Project IDs

Project ID:PC11407-5377
External Project ID:NSTC114-2320-B182-020
StatusActive
Effective start/end date01/08/2531/07/26

Keywords

  • Enterovirus A71
  • Host protein IQGAP1
  • Exosome
  • Dihydroartemisinin

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.