Investigating the Pathogenic Mechanism Underlying Mutant Chchd2-Induced Hereditary Parkinson'S Disease.

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Project IDs

Project ID:PC10708-1483
External Project ID:MOST107-2320-B182-036-MY3
Effective start/end date01/08/1831/07/19


  • Parkinson's disease
  • CHCHD2
  • Autosomal dominant familial type 22 of Parkinson's disease (PARK22)
  • Substantia nigra dopaminergic neurons
  • Mutant CHCHD2 knockin mouse
  • Structural abnormality of mitochondria
  • Mitochondrial dysfunction
  • Oxidative stress
  • Mitochondrial apoptotic pathway
  • Transcriptional dysregulation
  • Synaptic dysfunction.


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