Investigating the Pathogenic Role of Follicular T Helper Cell and Its Potential as a Therapeutic Target in Rheumatoid Arthritis

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

在我們前導實驗中發現,新確診類風濕性關節炎且未接受過任何治療的患者中,血中作用型Tfh細胞的比例變高,並且與疾病嚴重度呈高度正相關。我們將使用 超高參數流式細胞儀來分析類風濕性關節炎與退化性關節炎患者的外周血樣本和關節滑膜腔組織,用以建立類風濕性關節炎治療前後的免疫細胞資料庫。我們也將利用小鼠關節炎模式來研究作用型Tfh細胞促使類風濕性關節炎病發的機轉,並以針對作用型Tfh細胞來開發新的類風濕性關節炎療法。

Project IDs

Project ID:PC11207-1317
External Project ID:NSTC112-2314-B182-015-MY3
StatusFinished
Effective start/end date01/08/2331/07/24

Keywords

  • rheumatoid arthritis
  • follicular T helper cell
  • biomarker
  • Bcl6
  • IL21
  • CAR-NK therapy

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