Investigation for the Mechanism of Radiotherapy to Activate Cd8+ T Cells against Lung Cancer and Biomarkers Measurement for Predicting Clinical Immunotherapeutic Efficacy

Cheng, Chun-Chia (PI)
Chang, Chun‑Chao (CoPI)
Wang, Chih‑Liang (CoPI)

Research Center for Radiation Medicine

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Abstract

臨床上肺癌為高發生率與高致死率的癌症，肺癌病人免疫治療在臨床上只有20%的療效，如何增加免疫治療療效是臨床重要課題之一。放射治療除抑制癌細胞增生，亦會釋放干擾素及細胞激素活化免疫細胞，本研究將釐清放射治療活化癌病人的免疫活性分子機轉，並據以開發新型癌症藥物及評估T細胞CXCR3等做為臨床免疫治療療效的生物標記，將有助於未來發展精準肺癌個人化治療。

Project IDs

Project ID:PC11207-1482
External Project ID:NSTC112-2314-B182-048

Status	Finished
Effective start/end date	01/08/23 → 31/07/24

Keywords

Cancer
CD8+ T cell
CXCL10
PD-L1
ICAM-1
Radiotherapy
Immunotherapy

Access Project

https://www.grb.gov.tw/search/planDetail?id=15462234

Investigation for the Mechanism of Radiotherapy to Activate Cd8+ T Cells against Lung Cancer and Biomarkers Measurement for Predicting Clinical Immunotherapeutic Efficacy

Project Details

Abstract

Project IDs

Keywords

Access Project

Fingerprint