Investigation of Long-Term Cardiorenal Protective Effects of Traditional Chinese Medicine on Metabolic Syndrome: Big Data Analysis and Pharmacological Validation

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

這項研究探討了中藥在治療代謝症候群及相關疾病(如肥胖和非酒精性脂肪肝病)的長期療效。透過整合臨床數據、生物資訊分析和實驗室驗證,旨在找出針對高血脂、高血壓和高血糖等代謝症候群的核心中藥,並確認其心腎保護效果後,使中藥組合可能成為代謝症候群的可持續治療方法,透過結合長庚研究數據庫(CGRD)和台灣精準醫學計劃(TPMI)的基因組數據,亦可找出影響中藥成功診治代謝症候群和體重的因子。此外,研究還將探索調節脂質代謝的中藥及其活性成分,預測其潛在的靶蛋白和分子途徑,深入探討中藥如何影響脂肪自噬(脂滴的自噬降解)和脂質堆積,為代謝症候群的脂質管理提供新治療策略,可作為重要之臨床與學術發展之參考。

Project IDs

Project ID:PC11407-5434
External Project ID:NSTC114-2320-B182-008
StatusActive
Effective start/end date01/08/2531/07/26

Keywords

  • Metabolic Syndrome
  • Chinese Herbal Medicine
  • Network Pharmacology Analysis
  • Long-Term Efficacy
  • Cardio-Renal Protection

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