Project Details
Abstract
Aging, the accumulation of change in a creature over time, is a universal process for all organisms.
Aging is a critical risk factor for a variety of human disease, such as Alzheimer’s disease.
Plumula Nelumbinis (Nelumbonaceae) obtains many different skeleton components, including benzyl
isoquinolones, aporphines, flavonoids, triterpenoids, steroids and polyphenols. Literature reports indicated
that pure components or crude extracts of Plumula Nelumbinis showed anti-oxidant, anti-arrhythmic and
anti-diabetic bioactivities.
Ethanolic extract of Plumula Nelumbinis (10 μg/ml) could effectively extend yeast (Saccharomyces
cerevisiae) life span 15% in Mother enrichment program (MEP) system. At the same concentration,
ethanolic extract of Plumula Nelumbinis could increase the replicative life span to 29.0 generations in
replicative life span (RLS) system.
This study aims to look for extending yeast life span principles from Plumula Nelumbinis by virtue of
bioassay-directed isolation and structural elucidation. The results could provide evidences for the
chemotaxonomy of this plant and bioactive principles in anti-aging research.
Project IDs
Project ID:PC10607-0089
External Project ID:MOST106-2320-B182-006
External Project ID:MOST106-2320-B182-006
| Status | Finished |
|---|---|
| Effective start/end date | 01/08/17 → 31/07/18 |
Keywords
- Plumula Nelumbinis
- aging
- replicative life span
- yeast
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