Leptospiral Biofilms and the Impact on Leptospirosis Chronic Kidney Disease

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

本研究將以體外細胞及體內動物感染模式探討鉤端螺旋體菌生物膜的結構和生物功能性及瞭解生物膜的角色與免疫耐受性和調節宿主免疫之相關性。此研究將有助於瞭解鉤端螺旋體菌生物膜對鉤端螺旋體病導致慢性腎臟疾病發病機制的影響。研究目標將提供未來的抗生物膜治療策略之基礎發展,而該策略旨在有效地抑制/根除鉤端螺旋體菌感染後在腎臟所生成的生物膜。預期未來研究成果對於學術界、社會健康維護及因鉤端螺旋體病導致的慢性腎病所帶來的社會經濟影響都有其助益。

Project IDs

Project ID:PC11106-0088
External Project ID:MOST109-2314-B182-050-MY3
StatusFinished
Effective start/end date01/08/2231/07/23

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