Project Details
Abstract
Eexercise provides numerous healthful effects, such as to cut the risk of heart disease,
improve in the delivery of oxygen to our body muscles, decrease the mental anxiety, and
lower the blood pressure and cholesterol levels. However, the media reported the injuries of
top athletes, the potential for heat exhaustion and collapse by runners during races, which
may be caused by elevated levels of oxidative stress that damages human health. The
volume, intensity and specific mechanisms underlying the beneficial health effects of
exercise are debatable and often difficult to assess. With the holistic characteristics,
metabolomics has been established as a powerful platform, yet highly sensitive tool to apply
in sports science. Unlike transcripts or proteins that often take hours, days or even weeks to
change, metabolites are the end products of a reaction and closely reflect underlying
physiological processes. For this reason, the outputs of metabolomics are highly sensitive
indicators of an organism’s physiological or disease status. We had initiated examining the
difference among 100 (sprint group) and 3000 (endurance group) meter run of university
elite male athletes and age-matched sedentary/healthy males (control group) by using
metabolomics as key platforms. Ames of the present study are to investigate whether the
interventions of sport strength, exercise training, and supplementation alter the body global
metabolic profiles or the targeted metabolites, such markers of the oxidative stress. To
complete the theme of this on-going research as proposed by the proved contract no.
IRB101-5042A3, we continue to propose the study of resveratrol as an antioxidant
supplement to the exercise training, that is, to compare the effects of metabolic profiles, to
identify and quantify the changes of metabolites, and to evaluate levels of oxidative stress
with the intervention of resveratrol on the exercises between elite sprint and long-distance
runners, which may benefit the performance of elite athletes. The results obtained from this
serious study will offer fresh insight into sports and exercise science, and may further
present a framework for assessing studies in exercise physiology. In addition, they will
provide a better understanding of exercise physiology to guide individuals wishing to attain
their objectives of optimal fitness and health with minimal risk, and update the knowledge
base of exercise physiology.
Project IDs
Project ID:PC10408-1254
External Project ID:MOST104-2410-H182-015
External Project ID:MOST104-2410-H182-015
Status | Finished |
---|---|
Effective start/end date | 01/08/15 → 31/07/16 |
Keywords
- Metabolomics
- global metabolic profiles
- targeted metabolites
- resveratrol
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