Project Details
Abstract
Eexercise provides numerous healthful effects, such as to cut the risk of heart disease,
improve in the delivery of oxygen to our body muscles, decrease the mental anxiety, and
lower the blood pressure and cholesterol levels. However, the media reported the injuries of
top athletes, the potential for heat exhaustion and collapse by runners during races, which
may be caused by elevated levels of oxidative stress that damages human health. The
volume, intensity and specific mechanisms underlying the beneficial health effects of
exercise are debatable and often difficult to assess. With the holistic characteristics,
metabolomics has been established as a powerful platform, yet highly sensitive tool to apply
in sports science. Unlike transcripts or proteins that often take hours, days or even weeks to
change, metabolites are the end products of a reaction and closely reflect underlying
physiological processes. For this reason, the outputs of metabolomics are highly sensitive
indicators of an organism’s physiological or disease status. We had initiated examining the
difference among 100 (sprint group) and 3000 (endurance group) meter run of university
elite male athletes and age-matched sedentary/healthy males (control group) by using
metabolomics as key platforms. Following this on-going research, we will conduct a
two-year work to better understand physiological changes that occur under different exercise
conditions. Aims of present study are to investigate whether sports, strength, exercise
training and other sports nutrition intervention alter the body global metabolic profiles or the
targeted metabolites, such markers of the oxidative stress. For the first year, to compare the
effects of metabolic profiles; to identify and quantify the changes of metabolites; and to
evaluate levels of oxidative stress with a race intervention among elite sprint, elite endurance,
and control groups. For the second year, to compare and evaluate the effects of resveratrol
supplementation on the exercise induced oxidative stress between elite sprint and
long-distance runners, which may benefit the performance of elite athletes. The results
obtained from our studies will offer fresh insight into sports and exercise science, and may
further present a framework for assessing studies in exercise physiology. In addition, they
will provide a better understanding of exercise physiology to guide individuals wishing to
attain their objectives of optimal fitness and health with minimal risk, and update the
knowledge base of exercise physiology.
Project IDs
Project ID:PC10308-1814
External Project ID:MOST103-2410-H182-020
External Project ID:MOST103-2410-H182-020
Status | Finished |
---|---|
Effective start/end date | 01/08/14 → 31/07/15 |
Keywords
- Metabolomics
- global metabolic profiles
- targeted metabolites
- a race
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