Modulated effects of Longdan Xiegan Tang on systemic lupus erythematosus of MRL lpr/lpr mice

Project: Ministry of Health and WelfareMinistry of Health and Welfare Commission Research

Project Details


Systemic lupus erythematosus (SLE) is a chronic multisystem disorder of presumed autoimmune origin in which cytotoxic antibodies, or circulating immune complexes, give rise to tissue damage often resulting in end organ disease and even mortality. Longdan Xiegan Tang (LDXGT) is a traditional Chinese medicine with purge gandanshihou (瀉肝膽實火) and clear xiajiaoshire (清下焦濕熱) effects. In addition, LDXGT has significant effect on oxygen free radicals and lipid peroxidation. In the present study we investigate its immunomodulatory effect on inhibiting autoimmune disease in MRL lpr/lpr mice. MRL lpr/lpr mice treats daily with LDXGT (50, 100, 200, 500 mg/kg/d orally) for 8 weeks. We will study the pathological effect of kidney tissue and progression in anti-ds-DNA production, proteinuria, lymphadenopathy. The protein expression profiles in kidney tissue that are associated with the physiological and pathological change during SLE progression will be analyzed by two-dimension gel electrophoresis and image analysis. Furthermore, we will assess the possible mechanism underlying the therapeutic effect of LDXGT in blood nitric oxide and lipid peroxidation levels. The study would fill a long-existing gap in Chinese medicine in the pathophysiological disorder of SLE. It may also lead to the discovery of potentially useful herb drugs for treating SLE in human patients.

Project IDs

Project ID:PG9601-0248
External Project ID:CCMP96-RD-024
Effective start/end date01/05/0730/04/08


  • Systemic lupus erythematosus
  • Longdan Xiegan Tang


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