Modulation of Brain Tumor Immunotherapy by Conventional Enhanced Delivery and Focused Ultrasound

Malignant glioma is the most common primary brain tumor, despite of aggressive treatments including surgical resection, radiotherapy and chemotherapy, the outcome is still disappointing. Recently, the roles of immune modulation in tumor progression have been highly addressed, numerous strategies for treat malignant brain tumors were reported, and immunotherapy for brain tumor is one of the most potential treatments. However, how standard chemotherapy influence patient`s immunity still unclear. On the other hand, the specialized blood brain barrier (BBB) restricts most of immune enhancer therapeutics and circulating immune cells to reach parenchyma for brain disease treatment. For enhancement of treatment effect on brain tumor, disturbing BBB may help to modulate the brain tumor microenvironment for immunotherapy. In our previous studies, local delivery of chemotherapy agent had been achieved by conventional enhanced delivery (CED), which demonstrates the potential of local delivered agent are able to interfere the microenvironment of brain tumor. Furthermore, locally administrated focused ultrasound (FUS) was proven to modulate the immune response against brain tumors. However, the potential synergistic effect of CED and FUS on immune modulation is still unknown. In the present study, we would like to investigate the response of regional immunity of brain tumor following conventional chemotherapy, and modulate the brain tumor microenvironment through CED and FUS to improve immunotherapeutic effect for tumor treatment. Potential regulation mechanism will be studied in animals for further applications.

Project ID:PC10507-0285
External Project ID:MOST105-2314-B182-007