Modulation of Ger-Gen-Chyn-Lian-Tang on Hepatic Bile Acid Homeostasis and Ubiquitin Proteasome System in High-Fat Diet Induced Non-Alcoholic Fatty Liver Disease and Farnesoid X Receptor-Deficient Hepatocellular Carcinoma Mice

Lee, Tzung-Yan (PI)

School of Traditional Chinese Medicine

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Abstract

法尼醇X受體FXR被認為是肥胖和2型糖尿病的治療靶點。本計畫將證明葛根芩連湯影響腸肝循環法尼醇X受體FXR所調節的代謝網絡。整體重點會呈現葛根芩連湯對法尼醇X受體FXR的激活效益及其對膽汁酸依賴性機制在腸道微生物菌叢的影響。計畫成果能夠進一步說明葛根芩連湯參與法尼醇X受體FXR、膽汁酸與泛素-蛋白酶體系統在腸肝循環的代謝途徑，對於非酒精性脂肪肝治療可以開啟新面向。同時也能提供脂質、葡萄糖、胰島素調控異常的疾病如肥胖，糖尿病有用的參考價值。

Project IDs

Project ID:PC11108-0172
External Project ID:MOST109-2320-B182-023-MY3

Status	Finished
Effective start/end date	01/08/22 → 31/07/23

Keywords

Ger-Gen-Chyn-Lian-Tang
non-alcoholic fatty liver
farnesoid X receptor
bile acid
ubiquitin-proteasome system

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https://www.grb.gov.tw/search/planDetail?id=14603879

Modulation of Ger-Gen-Chyn-Lian-Tang on Hepatic Bile Acid Homeostasis and Ubiquitin Proteasome System in High-Fat Diet Induced Non-Alcoholic Fatty Liver Disease and Farnesoid X Receptor-Deficient Hepatocellular Carcinoma Mice

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