Molecular Analysis of Hla Class I and II Associated Susceptibility to Neuroinflammatory Diseases in Children

Neuroinflammatory diseases are clinically heterogeneous and one of the major causes of acquired neurological disability. An underlying complex genetic susceptibility may play an important role in their etiologies; however, the role of genetic factors in determining their clinical features is still unclear. Neuroinflammation disease included multiple sclerosis, Acute disseminated encephalomyelitis, Acute necrotizing encephalopathy and nonparaneoplastic limbic encephalitis. The etiology of neuroinflammation diseases were still unknown, but immunogenetic mechanism has been suggested. The human leukocyte antigen system (HLA) is the name of the major histocompatibility complex (MHC) in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes reside on chromosome 6, and encode cell-surface antigen-presenting proteins and many other genes. The major HLA antigens are essential elements for immune function. Different classes have different functions. HLA typing divided into two group: type I (HLA-A, B & C) and type II ( HLA- DP, DQ & DR). HLA have other roles. Diversity of HLA in human population is one aspect of disease defense. They may protect against or fail to protect (if down regulated by an infection). They may mediate autoimmune disease (examples: type I diabetes, coeliac disease). Therefore we studied HLA determinants in children consecutively diagnosed with neuroinflammatory disease to study the immunogenetic peculiarities of neuroinflammatory diseases in children.

Project ID:PC10107-0358
External Project ID:NSC101-2314-B182-034