Molecular Investigation of the Promoting Effect of Bpc 157 on Tendon Healing and Study of Enhanced Therapeutic Efficacy

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

Since the isolation of pentadecapeptide BPC 157 from gastric juice in 1993, it is now known to exert protective effect on different tissues or organs. However, the underlying acting mechanism is not yet clear. Our laboratory has investigated the functions and molecular mechanism of BPC 157 and we found that BPC 157 can promote angiogenesis both in vivo and in vitro. BPC 157 can increase the number of mesenchymal stem cells isolated from bone marrow and promotes the homing function of mesenchymal stem cells to vascular endothelial cells. Besides these two beneficial functions to the healing of injured tendon, we also demonstrated that BPC 157 can increase the gene expression of growth hormone receptor and the addition of growth hormone can accelerate the proliferation of tenocytes. Therefore, we plan to investigate the in vivo effect of BPC 157 combined with growth hormone on rat Achilles tendon injury. The in vitro effect of combined treatment on the functions of tenocytes will also be studied. In addition, the regulation and function of novel protein HP33 will also be explored. The healing of injured tendon is always a difficult question and currently only surgery is applied clinically for severe tendon injury. This study investigates a new combined therapy for tendon healing based on our research findings. Since BPC 157 has been proven not toxic to human and growth hormone is approved by FDA. The success of our study can be easily applied to clinic use in the future. Therefore, this research project is important and worth to be investigated.

Project IDs

Project ID:PC10507-0238
External Project ID:MOST105-2314-B182-014-MY2
StatusFinished
Effective start/end date01/08/1631/07/17

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