Molecular Mechanism of Polydrug Abuse---Amphetamine and Ketamine Interaction in the CNS

The issue of drug abuse is escalating in Taiwan, especially nowadays people in the pub would abuse multiple drugs. The complexity of polydrug abuse and its potential drug interaction, toxicity or adverse effects have limited information. We intend to investigate the combination effect of amphetamine, the number one abused substance in this island and ketamine, because increasing people abused these two substances while no detailed medical information is available. We intend to study (1) the effect of ketamine on amphetamine metabolism by using capillary electrophoresis analysis; (2) effect of ketamine on amphetamine behavioral sensitization and (3) the neurochemical variation caused by combination use of amphetamine and ketamine. We expect through this study, one can gain better understanding about the cellular mechanism underlying the simutaneous use of amphetamine and ketamine.

Project ID:PG9101-0798
External Project ID:DOH91-NNB-1005