Non-Pharmacological Interventions on Cognitive Functions in Older People with Mild Cognitive Impairment

Mild cognitive impairment (MCI) is a common clinical syndrome that identifies people at high risk of developing dementia, and the prevalence range from 7.7 to 51.7%. Although treatments for MCI are currently unavailable, preliminary evidence has identified potential neuro-protective effects of physical activity (PA) and cognitive rehabilitation (CR), which may lead to improved outcomes. However, the design and delivery of an appropriate programme for people with MCI is challenging for having physical, psychological, cognitive, and social barriers. This project is proposed to be a three-year project. The purposes of this project are to develop and examine physical activity program, cognitive rehabilitation training, and new life-style (combination of exercise and cognitive) interventions on primary outcomes (cognitive function & IADL), and secondary outcomes (physical fitness, QOL, social support and depression) among community-dwelling elderly adults with MCI. We will develop a PA stage-matched intervention (SMI) (1st year), CR (2nd year) and New lifestyle program base on the literature and our previous findings, then, 64 elderly adults with MCI will be recruited in to a 2-group pretest-posttest randomized controlled trial for 6 months and a 6-month follow-up to examine its effectiveness among community-dwelling elderly with MCI. The 72 and t test will be used to test for differences between two groups; to address the effect of the intervention, the data will be analyzed using a mixed model (intend to treat). The results of this study can help health care providers in Taiwan to individualize their interventions to the specific needs' of the elderly, thus helping to prevent from cognitive decline among community-dwelling elderly with MCI.

Project ID:PC10501-2038
External Project ID:MOST104-2314-B182-029-MY3