Pcsk9 Inhibition in Patients with Acute Stroke and Symptomatic Intracranial Atherosclerosis - a Prospective, Randomized, Open-Label, Blinded End-Point Study with High-Resolution Mr Vessel Wall Imaging

Huang, Yen-Chu (PI)
Lee, Meng (CoPI)
Lee, Jiann-Der (CoPI)
Lin, Leng Chieh (CoPI)
Tsai, Yuan Hsiung (CoPI)
Yang, Jen-Tsung (CoPI)

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Abstract

顱內動脈硬化狹窄之中風，通常復發率高且易導致永久殘障，目前的治療藥物主要是雙重抗血小板和高強度Statin，但高強度Statin藥物通常有較高的副作用,治療效果無法達成。本研究是使用高解析度MRI對來自ICAS的急性缺血性中風病人進行研究，以評估PCSK9單克隆抗體alirocumab的療效和安全性。我們假設在Statin類藥物治療的背景下，加上alirocumab治療可穩定顱內斑塊且減低動脈狹窄程度。目前試驗登錄資料中並無相關進行中的研究，如本研究可觀察到正向的結果，未來值得進行phase 3的試驗，探討PCSK9抑制在有症狀顱內動脈硬化狹窄病人中的療效，進而降低再中風風險。

Project IDs

Project ID:PC11007-0469
External Project ID:MOST110-2314-B182-056

Status	Finished
Effective start/end date	01/08/21 → 31/07/22

Keywords

Intracranial atherosclerotic stenosis
alirocumab
PCSK9
MRI

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https://www.grb.gov.tw/search/planDetail?id=13866401

Pcsk9 Inhibition in Patients with Acute Stroke and Symptomatic Intracranial Atherosclerosis - a Prospective, Randomized, Open-Label, Blinded End-Point Study with High-Resolution Mr Vessel Wall Imaging

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Abstract

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