pH Sensor and Breast Cancer Biomarker Detection by Using Novel Ir Nanostructure Modified SiO2 Membrane on Silicon Nanowire Field-Effect-Transistor

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

In order to control the breast cancer death rate, a solid state complementary metal-oxide-semiconductor (CMOS) based biosensor is important because of low cost, easy fabrication method, and quick detection. Despite the major advancement in breast cancer treatment, it is one of leading cause of death among women due to lack of symptoms and early detection. X-ray mammography is method to detect tumor but it has lower sensitivity in young women. As compared to mammography, magnetic resonance imaging is more sensitive for identification of breast cancer but it is quite expensive and time consuming, which limits its application in mass screening. Recently, identified lysyl-oxidase-like-2 (LOXL2) enzyme expression indicates the progression of breast cancer metastasis, which can be quantified by measuring hydrogen peroxide (H2O2) resultant of enzyme-substrate reaction in in-vitro condition. Due to low oxidation potential of iridium (Ir), this has strong potential to measure H2O2 as well as LOXL2 enzyme. An early growth of LOXL2 enzyme or high sensitivity of <100 pM will be detected by using novel Ir nano-net modified SiO2 sensing membrane in Si nanowire ISFET for the first time. On the other hand, LOXL2 enzyme can be immobilized by using antibody on pure SiO2 sensing membrane in Si nanowire FET as well as Immuno-FET. This is another promising approach for the direct measurement of LOXL2 using immune reaction at the gate surface. Therefore, the Ir nanostructures can be used to catalyse the H2O2 reduction at the SiO2 surface and have potential to detect the cancer progression with high accuracy using ISFET structure. Its repetitive use and fast speed allow the monitoring of tumor progression and application in drug designing also. A lower concentration of biomarker with high precision and speed must be controlled by using Si nanowire FET. Initial H2O2 detection can be also studied by using a simple electrolyte-insulator-semiconductor (EIS) structure and then, ISFET will be used for LOXL2 enzyme detection. The outcomes of novel Ir nanostructure modified SiO2 sensing membrane based ISFET or nano-biosensor have been discussed point-wise for three years below.

Project IDs

Project ID:PB10408-5748
External Project ID:MOST104-2221-E182-075
StatusFinished
Effective start/end date01/08/1531/07/16

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