Precise Medicine to Prevent Recurrent Mood Episodes in Bipolar Disorder: from Retrospective Cross-National Trials Emulation, to Prospective Pragmatic Trials Validation (Continuation Proposal)

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

對躁鬱症預防復發的精準用藥做一系列研究,包括用跨國資料庫的回顧性目標擬真試驗與收案的前瞻性臨床務實試驗。預期(1)仿臨床試驗規格的回顧性研究,調查躁鬱症病患穩定期的推薦用藥,包括預防任何和特殊(鬱/躁)情緒復發的理想藥物組合、其適當藥物劑量和藥物間交互作用;結果將提供臨床精準選擇適合的藥物,降低病患復發的風險與避免病患走向慢性失能。(2)藉由情感分析與生理訊號分析的結果,發展臨床上探索躁鬱症患者情緒狀況的新工具;結果可讓醫師更精準地評估病患的病情。(3)與國外學者合作跨國資料,將可提升團隊學術品質與台灣學術能量。

Project IDs

Project ID:PC11207-0110
External Project ID:NSTC112-2314-B182-070-MY3
StatusFinished
Effective start/end date01/08/2331/07/24

Keywords

  • bipolar disorder
  • recurrence
  • precision medicine
  • data mining
  • target trial emulation
  • pragmatic trial

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