Project Details
Abstract
The mortality rate of acute myocardial infarction steadily declines across
several populations since 1960. It has been attributed to better management of
arrhythmia, hemodynamic monitoring, heart failure treatment and several
reperfusion strategies. Although considerable advances have been made in the
management of patients with ST-elevation myocardial infarction, room for
improvement still exists. Characterization of patients who have higher risks for
developing mechanical or electrical complication or late mortality is current
important issues.
Because the onset of myocardial infarction and stroke has distinct circadian
patterns and cardiovascular diseases also occur at higher rates in individuals
with nighttime work or shift work, it is then suggested that circadian rhythm are
important factors in cardiovascular diseases. We have reported that mice with a
Per2 mutation have premature vascular senescence, impaired angiogenesis and
decreased endothelial progenitor cell function. However, it is not known if
circadian genes play any role in the acute myocardial infarction patients.
We have proposed three specific aims based on our previous results. First,
we will analyze the circadian rhythm gene expression in the acute myocardial
infarction patients. Second, we will characterize the patients based on their
clinical disease course and correlate the clinical changes to their circadian gene
expression. Third, we will character their genotype and correlate to their
diseases severity. By accomplishing these three specific aims, we hope to
provide a new leads for the treatment of myocardial infarction.
Project IDs
Project ID:PC9808-1029
External Project ID:NSC98-2314-B182-060
External Project ID:NSC98-2314-B182-060
Status | Finished |
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Effective start/end date | 01/08/09 → 31/07/10 |
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