Prediction of Prognosis and Cardiac Function after Acute Myocardial Infarction with Circadian Activity

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

The mortality rate of acute myocardial infarction steadily declines across several populations since 1960. It has been attributed to better management of arrhythmia, hemodynamic monitoring, heart failure treatment and several reperfusion strategies. Although considerable advances have been made in the management of patients with ST-elevation myocardial infarction, room for improvement still exists. Characterization of patients who have higher risks for developing mechanical or electrical complication or late mortality is current important issues. Because the onset of myocardial infarction and stroke has distinct circadian patterns and cardiovascular diseases also occur at higher rates in individuals with nighttime work or shift work, it is then suggested that circadian rhythm are important factors in cardiovascular diseases. We have reported that mice with a Per2 mutation have premature vascular senescence, impaired angiogenesis and decreased endothelial progenitor cell function. However, it is not known if circadian genes play any role in the acute myocardial infarction patients. We have proposed three specific aims based on our previous results. First, we will analyze the circadian rhythm gene expression in the acute myocardial infarction patients. Second, we will characterize the patients based on their clinical disease course and correlate the clinical changes to their circadian gene expression. Third, we will character their genotype and correlate to their diseases severity. By accomplishing these three specific aims, we hope to provide a new leads for the treatment of myocardial infarction.

Project IDs

Project ID:PC9808-1029
External Project ID:NSC98-2314-B182-060
StatusFinished
Effective start/end date01/08/0931/07/10

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