Proteomics approach of activative components of Yin-Chen-Hao on steatohepatitis in leptin deficiency mice

Project: Ministry of Health and WelfareMinistry of Health and Welfare Commission Research

Project Details


Associated with a rising prevalence of obesity, cardiovascular diseases and hepatic steatosis is increasing in the world. We have engaged on the characteristics of various herbal medicines on hepatic disorder diseases for years, including hepatic fibrosis, apoptosis, and oxidative stress. Specifically, we focus on obesity-mediated hepatic oxidative stress and steatohepatitis, a model generated by leptin-deficiency have hypertriglyceridemia relative to normal mice. In the objective of current project proposal, we will apply the proteomics techniques to perform the study of molecular mechanism of biologic functions of scoparone, an active component of Yin-Chen-Hao that related to possible hepatoprotective responses. Therefore, the specific aims in this project are: Specific Aim I: We will clarify the activity of scoparone to leptin-deficiency induce obesity or steatohepatitis-mediated aberrant hepatic function, including oxidative stress; meanwhile, we also detect the potential factor(s) involved in fatty acid accumulation. Specific Aim II: We will identify and study the “possible” compounds, scoparone, originated from Yin-Chen-Hao responsible for lipogenesis and steatosis. Especially investigate molecular mechanisms by possible scoparone -mediated signaling in regulation of fatty acid synthase. Specific Aim III: The main objective of this project is to conduct of proteomics approach in understanding the activity of scoparone and generate enough information to open the way to couple phytomedicine with genomic sciences.

Project IDs

Project ID:PG10001-0519
External Project ID:CCMP100-RD-016
Effective start/end date01/01/1131/12/11


  • obesity
  • steatohepatitis
  • Yin-Chen-Hao
  • scoparone
  • leptin


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