Quantifying Magnetic Moment or Susceptibility of Non-Isolated Small Objects by Using the Updated Cissco Method in Mri

Complex Image Summation around Cylindrical or Spherical Object (CISSCO) is a quantitative technique for extracting a particular object's magnetic moment or susceptibility in MRI. The potential clinical applications of this method are to reveal the oxygen saturation level in veins, distinguish microbleeds between hemorrhages and calcified spots, and monitor the disease progression of mild TBI or vascular dementia. While the precision and accuracy of CISSCO method have been extensively explored, the assumption of CISSCO method may restrain in-vivo applications inherently. This assumption is the particular object embedded around the uniform background in magnitude and phase images. However, only a few objects in vivo fit in this requirement. This research proposal will expand the capability of the conventional CISSCO method. In this updated method, we will utilize the concept of either the superposition principle or symmetry to solve the magnetic moment and susceptibility. In the superposition principle, we consider two objects as one big object and add the signal around this big object in images. In the concept of symmetry, we only integrate the signal around the object at the portion of less impact from the other object or heterogeneous environment in images. The preliminary results in the non-uniform environments have shown promising using these concepts. We will validate this updated method in the simulations and phantom images rigorously. These investigations in this proposal will lead to have wider selections of particular objects in-vivo to reflect patients' pathophysiological information by solving their magnetic moment or susceptibility.

Project ID:PB10707-0536
External Project ID:MOST107-2221-E182-023