Regional Comparison of the Impact of Outdoor Air Pollutants and Inflammatory Indicators on Fetal Growth in Women with Gestational Hypertension

  • Wan, Gwo-Hwa (PI)
  • Hsu, Te-Yao (CoPI)
  • Hung, Tai-Ho (CoPI)
  • Tsai, Ching Chang (CoPI)

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details


Gestational hypertension is one of common diseases in pregnant women and is an important factor resulting in death of pregnant women and fetuses. Gestational hypertension may cause adverse health effects for pregnant women and for fetuses through the influence on the characteristics and function of placentas. Limited studies were evaluated the associations among outdoor air pollutants exposure, inflammatory indicators, and fetal growth outcomes in women with gestational hypertension. The purpose of this study will be to evaluate the influences of outdoor air pollutants in northern and southern Taiwan areas on concentrations of inflammatory indicators in the blood of women with gestational hypertension, and how these air pollutants and inflammatory indicators impact fetal growth outcomes. In the three-year-project, the first two years of the project will recruit pregnant women aged 20 or above who are in their second trimester and live in northern (Taipei City, New Taipei City, Taoyuan City) and southern (Tainan City, Kaohsiung City, Pindong County) Taiwan areas, respectively. The pregnant women will be divided into two groups: group 1, healthy pregnant women; group 2, women with gestational hypertension who diagnosed at week 20 later. The pregnant women who have chronic diseases (cardiovascular disease, diabetes mellitus, and hypertension) and multiple gestations will be excluded and a total of 240 subjects in northern and southern areas of Taiwan will be recruited in this study. All the recruited pregnant women will be followed up starting from their second trimester until delivery. Data of personal characteristics and prenatal examination of recruited subjects and outdoor air pollutants concentrations will be obtained in this study. Also, the levels of inflammatory indicators in the blood of pregnant women and fetal cord blood, as well as fetal growth outcomes will be analyzed. This study will establish datasets of outdoor air pollutants exposure of women with gestational hypertension and healthy pregnant women in northern and southern areas of Taiwan, and concentrations of inflammatory indicators in the blood of pregnant women and fetal cord blood. Further study will evaluate whether outdoor air pollutants exposure is related to concentrations of inflammatory indicators in the blood of pregnant women and in fetal cord blood, and even to fetal growth outcomes.

Project IDs

Project ID:PC10907-1004
External Project ID:MOST109-2314-B182-043-MY3
Effective start/end date01/08/2031/07/21


  • pregnant woman
  • gestational hypertension
  • outdoor air pollutants
  • inflammatory reaction
  • fetal growth.


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