Relationships among Work Condition, Financial Consequences, and Quality of Life of Living Liver Donors

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details


Living donor liver transplantation is a risk to healthy living donors. Therefore, recovery of the physiological, psychological, and social aspects after surgery is an important issue. With the progress of surgical skill and post-operative care experience, the recovery of physiological aspects can be maintain steadily. The social aspect, for example, the working conditions after surgery has gradually received attention. Donors may face poor financial consequences and quality of life if they did not work after surgery. However, the work condition of living liver donor, the related factors of work condition, and the return to work trajectory were inconclusive because the definition of work was vary among studies, and the research design is mostly retrospective and cross-sectional in nature. Therefore, the purpose of this study was to explore the working conditions of living liver donors, factors related to working conditions, and the relationship among working conditions, financial consequences, and quality of life. This study lasted three years. The study design will combine the retrospective cross-section and prospective longitudinal design. Data will collect in a medical center at northern Taiwan. Convenience sample method was use to included study participants. For retrospective cross-sectional part, living liver donors who age 20 and above, have undergone liver donation surgery and discharge for more than 12 months, have been followed up in the research unit (hospital), and agreed to participate in this study. The number of samples is estimated to be 215. For prospective longitudinal part, the inclusion criteria is living liver donor who age 20 and above, undergoing living liver donation surgery, and agreed to participate in this study. Data were collected once before the donation surgery and 3, 6, 9 and 12 months after the surgery, a total of 5 times. The estimated number of samples is 142.Research tools include: Basic data questionnaire, donation symptom distress scale, Clavien's complications grading system, General Self-Efficacy Scale (GSE), depression subscale of Depression Anxiety Stress Scales-21, environmental factor questionnaire (e.g. support level), work condition questionnaire, financial consequences questionnaire, and quality of life scale (MOS-SF12).Descriptive statistical analysis such as mean, standard deviation or number and percentage is used to describe the frequency distribution of each study variable. Pearson correlation, chi-square test, t-test, or ANOVA analysis is used for bivariate analysis. Logistic regression is used to analyze the factors that affect the work condition, latent class analysis (LCA) is used to analyze the different work change pattern, and multiple linear regression was use to analysis the influencing factors of financial consequences and quality of life. Of the prospective longitudinal data analysis, latent class analysis (LCA) was used to analyze changes in working conditions. Latent growth curve modeling or generalized estimate equation model (GEE) will use to analyze changes in quality of life and financial consequences at different time periods and influencing factors. It is hoped that the research results can enrich the current understanding of the work condition of living liver donors, and serve as a theoretical basis for living donors’ candidacy assessment and the formulation of related interventions.

Project IDs

Project ID:PC10907-1141
External Project ID:MOST109-2314-B182-052
Effective start/end date01/08/2031/07/21


  • living liver donor
  • working condition
  • financial consequence
  • quality of life


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