Research and Development the Lead Compounds against A549 Cell Line (I~III)

According to the statistics by the Department of Health R.O.C., cancer is the major cause of top ten death in Taiwan. The death rate of cancer was 17.8% in 1990 and has increased to 28.4% in 2010, the casualty has increased by 10.6% in a period of 20 years. The mortality rate of lung cancer is the highest than other cancer. Thus, searching for the active candidate compounds from the plant extracts is urgently for the cure of lung cancer. In our studies on the cytotoxicity of natural sources, several species have been screened at present. Among them, we found the methanolic crude extracts of Kalanchoe tubiflora, Kalanchoe laciniata (L.) DC. and Euphorbia formosana Hayata showed significantly cytotoxic activities against A549 cell line (IC50 = 4.91, 4.12, 3.20 g/ml). We are also interested in investigating the constituents and bioactivities of K. tubiflora, K. laciniata (L.) DC. and E. formosana Hayata due to the less of phytochemical studies. This study aims to look for cytotoxic principles from K. tubiflora, K. laciniata (L.) DC. and E. formosana Hayata by virtue of bioassay-directed isolation and structural elucidation. The results could provide evidences for the chemotaxonomy of these three plants and bioactive principles against A549 cell line.

Project ID:PC10108-0879
External Project ID:NSC101-2320-B182-015