Role of Androgen in the Immunological Function of Rat Splenic Cells after Exercise Training

Androgens are critical to the regulation of immune functions under physiological or pathological conditions. Androgen attenuated inflammatory responses are through down-regulation of toll-like receptor 4 expression, and is widely used in the treatment of clinical inflammatory-associated diseases. Moreover, exercise training has been considered as the regulatory property of endocrine system as well as nonpharmacological anti-inflammatory abilities. However, the possible underlying mechanisms of androgens affecting immunological functions after exercise training are rarely addressed. Orchidectomy and exercise training, therefore, has been served as an useful experimental animal models in this project. The specific aims of this proposal are to examine the role of androgen in regulating immune functions as well as uncover the specific immune cell of splenocytes (splenic macrophage or splenic B, T lymphocyte) through exercise training. In the second year, we will investigate the effects of androgen on immune responses and mechanisms in splenocyte macrophage or B, T lymphocytes of orchidectomized rats. Through the present study, the cross-interaction between exercise training and androgen involved in the regulation of immune functions will be elucidated.

Project ID:PC10607-0361
External Project ID:MOST106-2410-H182-018