Role of Two-Component Regulatory System Covr/Covs-Mediated Bacterial Cell Wall Thickness Reduction on Extracellular Vesicle Release, Exportal Microdomain Integrity, and Liaf/Lias/Liar Three-Component Regulation System Activation in Group a Streptococcus

Chiang-Ni, Chuan (PI)
Chiu, Cheng Hsun (CoPI)

Department of Microbiology and Immunology

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Abstract

胞外囊泡為真核及原核細胞釋放蛋白質的機制之一。雖然細菌的胞外囊泡被認為在感染過程中扮演重要角色，但相較於真核細胞，目前對於細菌釋放胞外囊泡之機制所知較少，尤其在革蘭氏陽性細菌中更是如此。本計畫將以侵襲性化膿性鏈球菌作為研究標的，分析CovR/CovS二元調控系統影響胞外囊泡釋出效率之機制，並研究其所影響ExPortal微區域功能變化與胞外囊泡釋出及下游LiaF/LiaS/LiaR系統調控活性之相關性，預期可增加我們對革蘭氏陽性細菌胞外囊泡釋出機制之了解，並進一步提供這些微結構參與化膿性鏈球菌侵襲性感染的重要資訊。

Project IDs

Project ID:PC11407-5358
External Project ID:NSTC114-2320-B182-022-MY3

Status	Active
Effective start/end date	01/08/25 → 31/07/26

Keywords

Bacterial pathogenesis
Streptococcus pyogenes
Bacterial extracellular vesicle
Bacterial virulence factor secretion
CovR/CovS
LiaF/LiaS/LiaR

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Role of Two-Component Regulatory System Covr/Covs-Mediated Bacterial Cell Wall Thickness Reduction on Extracellular Vesicle Release, Exportal Microdomain Integrity, and Liaf/Lias/Liar Three-Component Regulation System Activation in Group a Streptococcus

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