Roles of the Na+/H+-Exchanger Nhe1 in the Regulation of [Ca2+]I and Glutamate and Gaba Responses in the Central Clock of the Rat Suprachiasmatic Nucleus

  • Huang, Rong-Chi (PI)

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Project Details

Abstract

能量代謝與生物時鐘關係密切。SCN旺盛代謝製造的酸，會透過鈉氫交換子NHE1排出胞外，以維持胞內nimodipine敏感性鈣離子的衡定。我們分析麩胺酸誘導鈣離子的動力學，以此為基探討NHE1對麩胺酸與GABA反應的調節。相信可以提供SCN研究領域一個新視角，有助了解生物時鐘與能量代謝的關係。

Project IDs

Project ID:PC11007-2812
External Project ID:MOST108-2320-B182-017-MY3
StatusFinished
Effective start/end date01/08/21 → 31/07/22

Keywords

  • suprachiasmatic nucleus
  • circadian rhythm
  • energy metabolism
  • membrane excitability
  • Na+/Ca2+-exchanger (NCX)
  • Na+/H+ exchanger (NHE)
  • Na+/K+-ATPase (NKA)
  • intracellular Ca2+
  • intracellular pH
  • extracellular pH
  • glutamate
  • GABA

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