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Screen the Targeting Dna Repair in Natural Products and Investigate the Molecular Mechanisms

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

新興的癌症個人療法有一大部分都是利用DNA修補蛋白間之合成至死特性來達成。大多的癌症都具有DNA修補基因的缺失,若能找到這些缺失基因的合成至死基因,並進行抑制,可針對這些癌症細胞進行專一性的毒殺。因此若能找尋更多的DNA修補蛋白抑制劑並了解且其分子機制,則有極大的潛力於未來成為癌症個人化醫療之藥物。

Project IDs

Project ID:PC11307-1705
External Project ID:NSTC113-2320-B182-004
StatusFinished
Effective start/end date01/08/2431/07/25

Keywords

  • DNA repair
  • double-strand break
  • DNA damage sensitivity
  • personalized cancer therapy

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