Stablish the Database of Extra-Hepatic Primary Malignant Neoplasm in Patients with Hepatocellular Carcinoma---(I) Investigate Clinical Manifestations and Prognosis; (II) Investigate the Risk Factors of Six Cancers with High Incidence Rates by Using a Ca

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details


Due to early diagnosis and prompt treatment of hepatocellular carcinoma (HCC), higher chance of developing extra-hepatic primary malignant neoplasm (EHPM) in clinical observation. Between 1987 and 2011, our preliminary data showed 372 cases (3.02%) developed EHPM in 12,368 HCC patients. Highest incidence of EHPM cancer site is colon cancer (n=55), followed by kidney cancer (n=40), bladder cancer (n=39), gastric cancer (n=34), lung cancer (n=30) and oral cancer (n=32) these six cancers et al. The etiology of EHPM needed further study. This study is planned to use 3 years to 1. Establish a complete EHPM database, and to investigate clinical manifestation, survival and secular change of cancer in our hospital retrospectively; 2. Under matched case-control design by using sex- and age±5years, EHPM survivor were selected from database and newly developed cases, to matched with HCC and individual cancer (colon cancer, kidney cancer, bladder cancer, gastric cancer, lung cancer and oral cancer) as 2 control groups, respectively. Life style such as smoking, alcohol consumption, diet habitus, occupation, environmental exposure, personal medical history, cancer treatment history, family cancer history and et al. were assessed with questionnaire, blood samples of all cases were collected to test viral hepatitis markers (HBsAg, Anti-HCV Ab). We expect that this study will explain 1. Clinical features, survival and secular change of EHPM; 2. The environmental and etiological relationship of colon, kidney, bladder, gastric, lung and oral cancers-related EHPM. This study has the most EHPM cases till now. We expect that our result is difficult to archive in Taiwan, even in foreign countries due to relative small sample size. Blood samples of all cases will be collected and stored. We plan to conduct basic study based on the result of case-control study, to investigate disease mechanism of EHPM in the future. This study will provide clinical practice information in preventive and treatment of secondary cancer in high risk groups of EHPM patients.

Project IDs

Project ID:PC10207-0393
External Project ID:NSC102-2314-B182-022
Effective start/end date01/08/1331/07/14


  • Extrahepatic primary malignant
  • Risk factor
  • Hepatocellular carcinoma
  • Survival


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