Study for Asymmetric Pattern-Formation Physical Field System of Genetic Morphogen Distribution in the Growth and Development of the Organismic Embryogenesis

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details


The developments of higher organisms are derived from embryos, while the embryo is composed of germ cells. They are divided into asymmetrical differentiation and resulting embryo axis, whereas this mechanism is generated by the regulation of concentration gradient distribution in the cells. To further understanding of how organisms control this mechanism, we use Drosophila as the animal model to explore. The Drosophila’s developmental manner is similar to the human’s embryonic development, of which there are different with dorsal-ventral and anterior-posterior axis. This axis which arose in the oogenesis determines the developmental stages. There are many of them participate in the regulation of signal paths. The determination of the body axis is mainly by a specific developmental stage in the performance of the oogenesis, called Gurken, which activate the neighboring molecules cell’s membrane epidermal growth factor receptor, triggering a downstream result of the molecular mechanism of transmission. In the middle of the oogenesis, Gurken along the dorsal-ventral axis formation in the oocytes showed the concentration gradient and asymmetric distribution between the dorsal and the ventral, and this dorsal-ventral asymmetric distribution becomes the key point to the dorsal-ventral axis. During the development of the embryo-splitting, cells can use information of each of their locations to go to different paths, and thus constitute a form of non-symmetrical shape contours with the helps of special chemical messages. However, although varieties of forms present non-symmetrical patterns, they have their own meaning to their acts. Explore the composition of its non-symmetrical shape, and then to analyze the pattern formation of Gurken distribution by using the group theory. This study will focus on the Gurken gradient distribution and the composition of the non-symmetrical pattern in the developmental stages of Drosophila oogenesis to produce a series of researches. Expecting to use these research methods to lead into the bio-molecular, and hope that we can have a deeper understanding to the asymmetric pattern formation of distribution during the process of biological development.

Project IDs

Project ID:PC10101-2207
External Project ID:NSC100-2112-M182-003-MY2
Effective start/end date01/08/1231/07/13


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