Study the Mechanism and Clinical Significance of Kpna2 and Plscr1 in Regulating Radiation-Induced Bystander Effect and Radioresistance/Chemoresistance

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

肺癌高居癌症死因之首。同步放化療已逐漸被用於治療晚期肺癌病患,然而難以預期的抗藥困境持續造成病患的不良預後。因此,找尋有效的生物標誌來預測與及時監控放化療效益是必須的,而抗藥的基礎研究是新藥開發的基石。本計畫可以 (1) 讓我們了解 KPNA2與 PLSCR1 參與調節抗放化療的新穎角色與機轉 (2) 提供研究 PLSCR1在癌細胞內、外發揮功能的多體學研究法以及具有發展潛力的生物標記 (3) 提供針對抑制 KPNA2 介導的抗放化療的新藥開發基礎。預期對國人健康及學術發展皆有正面的影響。

Project IDs

Project ID:PC11208-0894
External Project ID:NSTC111-2320-B182-019-MY3
StatusActive
Effective start/end date01/08/2331/07/24

Keywords

  • lung cancer
  • nucleocytoplasmic transport
  • proteomics
  • concurrent chemoradiotherapy
  • radiation-induced bystander effect
  • extracellular vesicle
  • secretome
  • interferon
  • interferon-stimulated gene
  • radioresistance

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