Studying the Association between Polysaccharide Intercellular Adhesin and the Activation of Saers Two-Component Regulatory System in Staphylococcus Aureus

Shu, Jwu-Ching (PI)
Kuo, An-Jing (CoPI)

Department of Medical Biotechnology and Laboratory Science

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Abstract

金黃葡萄球菌為造成院內感染的主要病原菌之一，其生物膜主要是由多醣類黏菌素 (PIA) 構成生物膜的基質。我們研究顯示PIA具有調控其它致病因子的功能，尤其是透過SaeRS二元調控系統，影響許多致病因子的表現及與宿主的交互作用，更為突顯PIA在構築生物膜外的重要角色。本研究可以對金黃葡萄球菌的致病機轉、在宿主體內免疫反應及逃脫的機制有更多的瞭解及臨床應用可能性。PIA也可做為抗菌製劑的標地，成為對抗多重抗藥性菌株的策略。

Project IDs

Project ID:PC11407-5354
External Project ID:NSTC114-2320-B182-026

Status	Active
Effective start/end date	01/08/25 → 31/07/26

Keywords

Staphylococcus aureus
polysaccharide intercellular adhesin (PIA)
SaeRS two-component system

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https://www.grb.gov.tw/search/planDetail?id=18012160

Studying the Association between Polysaccharide Intercellular Adhesin and the Activation of Saers Two-Component Regulatory System in Staphylococcus Aureus

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Abstract

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